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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Dec 13;64(24):18158–18174. doi: 10.1021/acs.jmedchem.1c01671

Figure 3. Structural design of P4-P2 cycloamide linked macrocyclic ketobenzothiazole (kbt) inhibitors of serine proteases.

Figure 3.

Cyclization is performed via a P4 Asp or Glu to a P2 Lys (A) or a Lys to an Asp or Glu (B).