Table 3.
Plasma stability of selected compounds in both mouse and human plasma.
| Compound | Mouse Plasma Stability t1/2 (min) |
Human Plasma Stability t1/2 (min) |
Mouse PPB (% free) |
|---|---|---|---|
| 15 | 178 | >289 | 85.3 |
| 16 | 274 | >289 | 18.4 |
| 17 | 156 | 151 | 25.9 |
| 18 (VD2173) | 222 | >289 | 28.6 |
| 19 | 157 | >289 | 6.0 |
| 20 | >289.1 | >289.1 | ND |
| 21 | >289.1 | >289.1 | ND |
| 22 | >289.1 | >289.1 | |
| 23 | 261.2 | 216.1 | |
| 24 | >289.1 | >289.1 | |
| 25 | >289.1 | >289.1 | |
| 26 | >289.1 | >289.1 | |
| 27 | 192.6 | 248.5 | |
| 28 | >289.1 | >289.1 | |
| 29 | >289.1 | >289.1 | |
| 30 | 276.8 | >289.1 | |
| 31 (ZFH7116) | 184 | 140 | 16.7 |
| 32 | >289 | >289 |