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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: Gene Ther. 2007 Feb 1;14(7):584–594. doi: 10.1038/sj.gt.3302897

Figure 5.

Figure 5

Correction of opsin distribution in the connecting cilia (arrows) of photoreceptor cells, following in vivo injection of LV-MYO7A(B). Opsin immunogold labeling of sections of photoreceptors from (a) a Myo7a+/+retina, (b) a Myo7a−/− retina, (c, d) a Myo7a−/− retina, infected with LV-MYO7A(B) at P1 and analyzed at P16. The photoreceptors in (c) are beneath an RPE cell that had correctly distributed melanosomes. Those in (d) are distant from the injection site, where the RPE melanosomes are all distributed as in MYO7A-null RPE cells. Scale bars: 500 nm. (e) Bar graph showing the concentration of opsin immunogold labeling in the cilia of photoreceptors like those in (a–d) (n = 43, 63, 28, and 17 cells, respectively). Error bars represent ±s.e.m.