Fig 1. Downregulation of ACE2 expression in mouse lung under sepsis- or acid aspiration-induced lung injury.

A-B, Protein expression of ACE2 in mouse lungs under sepsis at 48 hours after introducing cecal ligation puncture (CLP)-induced lung injury. Representative Western blot (A) and quantification of ACE2 protein abundance (B); sham control (n = 5) and CLP surgery (n = 5). C-D, Protein expression of ACE2 in mouse lungs at 24 hours after intra-tracheal instillation of acid in mice (0.02M HCl, 50 μl per body). Representative Western blot (C) and quantification of ACE2 protein abundance (D); sham control (n = 5) and acid inhalation (n = 5). All values are means ± SEM. Two-tailed unpaired t-test.