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. 2022 Jul 22;8(29):eabo0155. doi: 10.1126/sciadv.abo0155

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Fig. 1. — (A) Domain structure of human CRELD1 and CRELD2 and Drosophila Creld indicating protein identity of domains. (B) Single images from videos of w¹¹¹⁸ and Creld mutants, showing their walking behavior. (C) Startle-induced negative geotaxis (SING) assay of 2-day-old w¹¹¹⁸ and Creld mutants. (D) M-mode tracing of pixel movement of the adult heart. (E) Quantification of diastole, systole [not significant (ns), P = 0.43], and heart period. (F) Heart rate of w¹¹¹⁸ and Creld mutant flies. (G) Transmission electron micrographs of abdominal tissue of w¹¹¹⁸ and Creld mutant adults. Sections show myocardial cells. (H) Transmission electron micrographs of thorax tissue of w¹¹¹⁸ and Creld mutant adults. Sections show indirect flight muscles (IFMs). Boxes represent the interquartile range and median; whiskers represent minimum and maximum. ***P < 0.001.