Table 3. Voltage-dependence of activation and inactivation of Ca2+-currents in SN DA neurons.
Table 3—source data 1. Source data for data shown in Table 3.
elife-67464-table3-data1.xlsx (27.6KB, xlsx)
| Activation | Inactivation | |||||
|---|---|---|---|---|---|---|
| V0.5,act (95% CI) [mV] | kact (95% CI) [mV] | n/N | V0.5, inact (95% CI) [mV] | kinact (95% CI) [mV] | n/N | |
|
Control A (without Cav-blocker cocktail) |
–37.8 (−39.3,–36.3) | 9.17 (7.90, 10.6) | 16/8 | –52.7 (−53.9,–51.5) | 10.5 (−11.6,–9.48) | 16/8 |
|
+Cav blocker cocktail ("R-type") |
–29.9 (−30.8,–29.1)*** | 5.49 (4.73, 6.30)*** | 19/5 | –47.5 (−48.7,–46.4)*** | 9.15 (−10.2,–8.16) | 19/5 |
|
Control B (before SNX-482) |
–34.4 (−35.7,–33.2) | 9.68 (8.59, 10.8) | 9/6 | –52.9 (−53.7,–52.1) | 9.30 (−10.9,–8.61) | 9/6 |
| SNX-482 - sensitive current | –34.9 (−37.7,–32.0) | 10.6 (8.26, 13.3) | 9/6 | –44.6 (−46.9,–42.2)+++ | 10.1 (−12.1,–8.24) | 9/6 |