Skip to main content
. 2022 Jul 22;51:101576. doi: 10.1016/j.eclinm.2022.101576

Figure 2.

Figure 2

Humoral immune response predicts odds of omicron breakthrough infection. (a) Omicron breakthrough infections were reported in the 3 nursing homes included in the study, including 13 breakthrough infections among our study participants. The number of individuals included in our study, as well as the number of breakthrough infections among them are indicated for each household (A, B and C). We collected sera prior to the outbreaks (median (range) of 53 (49-60) days before the breakthrough infection, corresponding to 55 (49-59) days after the booster dose) (b) Levels of anti-Spike IgGs and neutralisation of omicron are indicated for individuals from the three households (A, B and C) having a subsequent confirmed breakthrough infection or not. (c) Levels of anti-Spike IgGs and neutralisation of omicron are indicated for individuals from the household A having a subsequent confirmed breakthrough infection or not. Data are provided as Binding Arbitrary Unit per mL (BAU/mL) (left) and neutralisation titers (ED50) (right). Comparisons were performed using the Mann-Whitney rank test. Green dots indicate individuals with an history of COVID-19 prior to their booster dose of vaccine. Pink dots indicate individuals with no previous COVID-19. The dashed line indicates the limit of detection of the neutralisation assay (30). The limit of detection of the anti-Spike assay is 3 BAU/mL. Black bars indicate the median.