Table 3.

Association of residues within position 37 with JDM, with effects of classical HLA alleles linked to these residues^a,b

Residue	Classical HLA allele linked to residue	Allele frequency in JDM	Allele frequency in controls	OR	95% CI	P-value
Tyr-37	–	0.37	0.31	-	-	-
Ser-37	–	0.21	0.26	0.65	0.57, 0.75	7.3 × 10−10
–	HLA-DRB1*01:01	0.10	0.12	0.76	0.65, 1.46	1.7 × 10−3
–	HLA-DRB1*15:01	0.11	0.14	0.66	0.57, 0.78	6.5 × 10−7
Phe-37	–	0.11	0.15	0.63	0.54, 0.75	1.1 × 10−7
–	HLA-DRB1*07:01	0.09	0.13	0.67	0.57, 0.79	2.8 × 10−6
–	HLA-DRB1*14:01	0.02	0.02	0.86	0.60, 1.24	0.42
Asn-37	–	0.31	0.24	1.13	1.06, 1.19	0.05
–	HLA-DRB1*03:01	0.19	0.12	1.66	1.46, 1.89	1.4 × 10−14

^aSummary statistics for individual residues derived from the omnibus model for position 37, with Tyr-37 used as the reference residue. Summary statistics for classical four-digit HLA alleles derived from case–control analysis of imputed HLA data. Alleles linked to these residues at position 37 but not represented were filtered out during QC.

^bAlpha threshold for statistical significance in the MHC region taken as 6.8 × 10⁻⁶ (47).