Table 3.

Enrichment of select canonical pathways and corresponding protein components associated with the ABO rs657152 variant

Pathway	Pathway components	Symbol	Expression Log ratio	Expression P-value
IL-15 suppression
	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.033	2.2E-07
	Insulin-like growth factor 1 receptor	IGF1R	-0.03	6.9E-11
	Ephrin type-B receptor 4	EPHB4	-0.034	2.0E-11
	Vascular endothelial growth factor receptor 3	FLT4	-0.074	1.2E-15
	* Hepatocyte growth factor receptor	MET	-0.056	1.2E-35
	* Ephrin type-A receptor 4	EPHA4	-0.058	1.0E-52
	Vascular endothelial growth factor receptor 2	KDR	-0.065	1.7E-56
	Insulin receptor	INSR	-0.108	2.7E-65
	Tyrosine-protein kinase receptor Tie-1	TIE1	0.09	2.9E-85
STAT3 signaling
	Interleukin-6 receptor subunit beta	IL6ST	-0.019	2.9E-09
	Insulin-like growth factor 1 receptor	IGF1R	-0.03	6.9E-11
	Vascular endothelial growth factor receptor 3	FLT4	-0.074	1.2E-15
	Vascular endothelial growth factor receptor 2	KDR	-0.065	1.7E-56
	Interleukin-3 receptor subunit alpha	IL3RA	-0.127	4.4E-63
	Insulin receptor	INSR	-0.108	2.7E-65
NF-κB signaling
	Insulin-like growth factor 1 receptor	IGF1R	-0.03	6.9E-11
	Vascular endothelial growth factor receptor 3	FLT4	-0.074	1.2E-15
	Vascular endothelial growth factor receptor 2	KDR	-0.065	1.7E-56
	Insulin receptor	INSR	-0.108	2.7E-65

^*Significantly associated with incident hospitalized respiratory infection (P < 5.9 × 10⁻⁴) in prospective analysis (Fig. 1).

Significantly associated with incident hospitalized pneumonia (P < 5.9 × 10⁻⁴) in prospective analysis (Fig. 1).