Table 3.
Enrichment of select canonical pathways and corresponding protein components associated with the ABO rs657152 variant
Pathway | Pathway components | Symbol | Expression Log ratio | Expression P-value |
---|---|---|---|---|
IL-15 suppression | ||||
Macrophage colony-stimulating factor 1 receptor | CSF1R | 0.033 | 2.2E-07 | |
Insulin-like growth factor 1 receptor | IGF1R | -0.03 | 6.9E-11 | |
Ephrin type-B receptor 4 | EPHB4 | -0.034 | 2.0E-11 | |
Vascular endothelial growth factor receptor 3 | FLT4 | -0.074 | 1.2E-15 | |
* Hepatocyte growth factor receptor | MET | -0.056 | 1.2E-35 | |
* Ephrin type-A receptor 4 | EPHA4 | -0.058 | 1.0E-52 | |
Vascular endothelial growth factor receptor 2 | KDR | -0.065 | 1.7E-56 | |
Insulin receptor | INSR | -0.108 | 2.7E-65 | |
Tyrosine-protein kinase receptor Tie-1 | TIE1 | 0.09 | 2.9E-85 | |
STAT3 signaling | ||||
Interleukin-6 receptor subunit beta | IL6ST | -0.019 | 2.9E-09 | |
Insulin-like growth factor 1 receptor | IGF1R | -0.03 | 6.9E-11 | |
Vascular endothelial growth factor receptor 3 | FLT4 | -0.074 | 1.2E-15 | |
Vascular endothelial growth factor receptor 2 | KDR | -0.065 | 1.7E-56 | |
Interleukin-3 receptor subunit alpha | IL3RA | -0.127 | 4.4E-63 | |
Insulin receptor | INSR | -0.108 | 2.7E-65 | |
NF-κB signaling | ||||
Insulin-like growth factor 1 receptor | IGF1R | -0.03 | 6.9E-11 | |
Vascular endothelial growth factor receptor 3 | FLT4 | -0.074 | 1.2E-15 | |
Vascular endothelial growth factor receptor 2 | KDR | -0.065 | 1.7E-56 | |
Insulin receptor | INSR | -0.108 | 2.7E-65 |