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. 2022 Jul 15;2022:6215573. doi: 10.1155/2022/6215573

Table 2.

Differential metabolites detected by mass spectrometry combined with gas phase.

ID Peak2 Similarity rt Count Mass MEAN T MEAN M VIP P-value Q-value FOLDCHANGE LOG_FOLDCHANGE
69 2-Hydroxybutanoic acid 923 5.90393,0 9 131 1.272515066 1.829157 1.299843399 0.030824766 0.054717746 0.695683796 −0.523496376
87 3-Hydroxybutyric acid 917 6.15207,0 9 147 25.48762597 38.1509 1.435772881 0.006906593 0.031058352 0.668074026 −0.581920125
228 L-malic acid 910 8.38126,0 9 73 15.02098304 24.18815 1.206850204 0.045844599 0.064707169 0.621005853 −0.68732123
407 Palmitoleic acid 903 11.4327,0 9 55 4.427715453 6.258029 1.236645983 0.049653209 0.067078325 0.707525543 −0.499145861
410 Palmitic acid 878 11.5306,0 9 117 20.90998716 28.73753 1.309850706 0.025056075 0.05026023 0.727619379 −0.458744127
68 Glycine 1 876 5.88319,0 9 102 3.920530889 5.969469 1.437149115 0.003623146 0.031058352 0.656763806 −0.606553473
144 glycerol 855 6.94956,0 9 205 14.73609113 22.11935 1.316507776 0.030374647 0.054407164 0.66620819 −0.585955005
234 Threitol 852 8.47978,0 9 217 0.320598289 0.534807 1.439750027 0.003284907 0.031058352 0.599465913 −0.738250374
273 Alpha-ketoglutaric acid 826 8.93667,0 9 73 4.392760756 7.040861 1.19046366 0.04958074 0.067035106 0.623895417 −0.680623882
172 Uracil 822 7.43667,0 9 241 0.382125402 0.661469 1.353053457 0.022060725 0.047455437 0.577691894 −0.791627843
184 Pelargonic acid 794 7.60111,0 9 215 0.046390864 0.07566 1.23255862 0.043826199 0.063362351 0.613151594 −0.705684289
222 Aminomalonic acid 791 8.28837,0 9 218 0.413476931 0.584889 1.244433147 0.031388031 0.055098631 0.706932665 −0.50035529
206 2-Deoxytetronic acid 780 8.01104,0 9 73 4.287775664 6.992805 1.380659529 0.007758549 0.031058352 0.613169609 −0.705641901
85 3-Hydroxypyridine 778 6.0817,0 9 152 0.233075193 0.349579 1.473437449 0.004190223 0.031058352 0.666731544 −0.584822111
127 4-Hydroxybutyrate 769 6.69919,0 9 233 0.018386599 0.032341 1.34064562 0.025110742 0.050307906 0.568527482 −0.814698006
427 heptadecanoic acid 745 11.985,0 9 117 0.110508121 0.168502 1.336703207 0.032082258 0.055556587 0.655828223 −0.608610108
197 Thymine 677 7.85356,0 9 270 0.043778381 0.066104 1.371605211 0.012906566 0.037801216 0.662263926 −0.59452182
110 Malonic acid 1 674 6.46348,0 9 141 0.120153186 0.212515 1.480974611 0.001576369 0.031058352 0.56538798 −0.822686883
99 Methyl phosphate 665 6.28585,0 9 241 0.115662474 0.211687 1.463936501 0.002727024 0.031058352 0.5463833 −0.872014707
207 Beta-alanine 2 643 8.03652,0 9 248 0.054056527 0.101364 1.421035491 0.014950627 0.039659996 0.533289189 −0.907010013
162 2,3-Dihydroxypyridine 633 7.28778,0 9 240 0.086432291 0.12972 1.393394351 0.006663844 0.031058352 0.666297891 −0.585760767
463 N-acetyl-5-hydroxytryptamine 1 590 13.2097,0 9 290 160.0062516 231.7193 1.303021085 0.041478731 0.061714361 0.690517501 −0.534250115
113 3-Aminoisobutyric acid 2 520 6.51726,0 9 57 0.32200107 0.496484 1.338967469 0.015637714 0.04020852 0.648562563 −0.624682345
307 1,2-Cyclohexanedione 4 517 9.492,0 8 205 0.101748813 0.181678 1.387571447 0.026616559 0.051576505 0.560051285 −0.836369152
216 Erythrose 1 514 8.18007,0 9 350 0.689931679 1.092036 1.272409468 0.028301472 0.052900868 0.631784782 −0.662494907
219 Capric acid 508 8.24689,0 9 117 0.161212023 0.274597 1.358543235 0.010727066 0.035339822 0.587086555 −0.768354878
146 2-Deoxyuridine 503 7.01356,0 3 81 0.000258002 0.659853 1.539040505 0.016123039 0.040576096 0.000390999 −11.32054852
377 D-altrose 2 487 10.8282,0 3 257 0.000258002 0.138383 1.541803731 0.000279156 0.031058352 0.0018644 −9.067072758
111 Methylmalonic acid 481 6.46941,0 9 226 0.210469269 0.423913 1.496235451 0.002203188 0.031058352 0.496491996 −1.010157634
285 Digitoxose 1 452 9.08156,0 3 73 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
246 trans-4-Hydroxy-L-proline 2 449 8.64244,0 3 186 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
88 Sulfuric acid 419 6.16896,0 9 281 0.759582216 1.140343 1.321189491 0.030078726 0.054199895 0.666099824 −0.586189695
218 2,4-Diaminobutyric acid 3 416 8.2337,0 9 103 0.177346978 0.279941 1.370608087 0.009107719 0.033074562 0.633516577 −0.658545725
425 d-Glucoheptose 1 412 11.9031,0 7 319 0.012258146 0.021077 1.315429516 0.039316399 0.060377704 0.581574962 −0.781962934
501 Isomaltose 2 410 15.118,0 7 73 0.21680148 0.330811 1.462708603 0.005347921 0.031058352 0.655363457 −0.609632863
211 N-acetyl-L-leucine 2 406 8.12433,0 8 86 0.058678762 0.087162 1.447579125 0.011125631 0.035834826 0.673218373 −0.570853545
309 L-homoserine 3 396 9.52289,0 6 290 0.052160115 0.075824 1.481796159 0.00209498 0.031058352 0.687909761 −0.539708769
77 2-Ketovaleric acid 2 393 5.97089,0 9 89 0.148017445 0.248358 1.44720369 0.004315057 0.031058352 0.595983832 −0.746654902
238 4-Acetamidobutyric acid 2 387 8.55919,0 9 174 0.262681494 0.414491 1.304395218 0.023923344 0.049245254 0.633744092 −0.658027703
343 Biuret 2 385 10.0571,0 6 171 0.131112438 0.11193 1.298491114 0.038783781 0.060035166 1.171379459 0.228208501
149 O-acetylserine 2 384 7.08467,0 3 116 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
170 Oxamide 382 7.37756,0 9 116 0.638063028 0.963743 1.375059784 0.010946865 0.035615566 0.66206751 −0.594949762
193 Resorcinol 364 7.74837,0 9 240 0.1893703 0.270561 1.422135343 0.028840031 0.053304636 0.699917794 −0.514742608
34 2-Ketobutyric acid 2 359 5.37696,0 9 174 3.895398713 6.310969 1.452753771 0.003819666 0.031058352 0.617242587 −0.69609049
495 Maltose 344 14.4673,0 3 204 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
506 Ergosterol 339 17.6037,0 7 129 0.038142477 0.170062 1.152056064 0.040476247 0.061105175 0.224285234 −2.156593449
290 D-erythronolactone 2 338 9.18748,0 9 244 0.233520567 0.335404 1.338741737 0.015238113 0.03989368 0.696237385 −0.522348811
417 Sinapyl alcohol 1 331 11.7691,0 3 241 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
416 N-acetyl-D-galactosamine 1 329 11.7478,0 3 202 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
114 3-Methylamino-1,2-propanediol 1 327 6.52733,0 9 116 0.145928713 0.251951 1.487710076 0.000575224 0.031058352 0.579194579 −0.787879996
92 4-Hydroxypyridine 326 6.20052,0 9 141 0.489927793 0.795927 1.451323971 0.002465951 0.031058352 0.615543839 −0.700066486
251 Cytosine 322 8.68941,0 9 314 2.509840552 4.082056 1.283159978 0.021963317 0.047357392 0.614847194 −0.701700187
507 Cholestane-3,5,6-triol, (3?5?6?- 321 18.7661,0 9 57 0.885146653 2.002186 1.387564892 0.006905578 0.031058352 0.442090187 −1.177587384
295 2-Carboxybenzaldehyde 318 9.29889,0 3 448 0.000258002 0.040566 1.54194144 0.001888566 0.031058352 0.006360115 −7.296731326
486 Alizarin 296 13.9349,0 3 192 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
255 Maleamate 2 272 8.72638,0 7 244 0.017984542 0.083238 1.133918922 0.023097427 0.048471018 0.216061427 −2.210486564
169 4-Acetylbutyric acid 2 265 7.37059,0 9 71 0.880439414 1.444854 1.436770641 0.018764895 0.043859407 0.60936233 −0.714627777
1 Analyte 1 0 4.85415,0 9 220 0.143627588 0.206994 1.412512528 0.009375416 0.03347991 0.693874841 −0.527252637
2 Analyte 2 0 4.86659,0 9 221 0.939179789 1.482562 1.223187422 0.048539846 0.066406466 0.633484237 −0.658619373
4 Analyte 4 0 4.906,0 9 127 25.04838891 40.41622 1.427277713 0.024022642 0.049336351 0.619760853 −0.690216464
9 Analyte 9 0 4.95133,0 9 56 0.076008724 0.130549 1.387105878 0.006481408 0.031058352 0.582225673 −0.780349639
13 Analyte 13 0 5.01281,0 9 281 0.519158543 0.88159 1.415956277 0.00432766 0.031058352 0.588888971 −0.763932441
14 Analyte 15 0 5.05415,0 9 89 0.126686366 0.194385 1.370732385 0.011314269 0.036061485 0.651727984 −0.617658153
15 Analyte 16 0 5.06096,0 9 71 0.14247583 0.254596 1.382415691 0.025128313 0.050323204 0.559614273 −0.837495336
16 Analyte 17 0 5.10467,0 9 248 0.189236239 0.277412 1.185862123 0.046349455 0.065033621 0.682149873 −0.551839351
17 Analyte 18 0 5.1217,0 9 71 0.23537597 0.369089 1.285237347 0.028223069 0.052841325 0.63772183 −0.649000828
21 Analyte 22 0 5.17593,0 9 160 0.117336438 0.227376 1.396764148 0.014713146 0.039462234 0.516045471 −0.954429902
26 Analyte 27 0 5.21607,0 9 207 1.534123014 2.442395 1.406790033 0.005116932 0.031058352 0.628122392 −0.670882394
28 Analyte 29 0 5.28378,0 9 318 0.490583082 0.81612 1.436795045 0.003319147 0.031058352 0.601116114 −0.7342844
29 Analyte 30 0 5.28985,0 9 141 0.424192495 0.699525 1.423841019 0.023362325 0.048722604 0.606400455 −0.72165726
31 Analyte 32 0 5.306,0 9 82 0.113890123 0.158043 1.300767064 0.041070167 0.061468223 0.720626315 −0.472676759
35 Analyte 36 0 5.38238,0 7 265 0.096659841 0.140997 1.323588558 0.026344832 0.051353772 0.685547745 −0.544670949
42 Analyte 43 0 5.50956,0 6 318 0.053147962 0.116636 1.389043774 0.004972626 0.031058352 0.45567417 −1.133925502
43 Analyte 44 0 5.53119,0 9 83 1.092646683 1.899617 1.374864683 0.014404096 0.039198218 0.575193161 −0.797881572
45 Analyte 46 0 5.57133,0 9 173 0.040681195 0.061956 1.280531443 0.032539528 0.055851534 0.656616292 −0.606877547
53 Analyte 54 0 5.69844,0 3 72 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
60 Analyte 61 0 5.77652,0 9 187 0.411739097 0.640732 1.381876488 0.034261264 0.056916913 0.642607665 −0.637989906
61 Analyte 62 0 5.78067,0 9 89 0.196207665 0.280779 1.249714074 0.032407158 0.055766689 0.698796716 −0.517055267
65 Analyte 66 0 5.85193,0 9 258 1.102739869 1.898571 1.45940324 0.002841114 0.031058352 0.58082638 −0.783821116
66 Analyte 67 0 5.86748,0 9 245 0.75141187 1.042003 1.340855538 0.014720908 0.039468767 0.721122764 −0.471683209
70 Analyte 71 0 5.91167,0 8 83 0.124600132 0.21066 1.460188 0.005923432 0.031058352 0.5914747 −0.757611636
71 Analyte 72 0 5.917,0 8 206 0.109884171 0.15268 1.26573403 0.041287114 0.061599284 0.719702949 −0.474526526
79 Analyte 80 0 5.97948,0 9 130 0.06545618 0.103826 1.457571818 0.002601319 0.031058352 0.630443919 −0.665560052
83 Analyte 84 0 6.06822,0 9 89 0.629883615 0.857153 1.348964908 0.02146227 0.046845666 0.734855621 −0.444467266
86 Analyte 87 0 6.1057,0 9 355 0.013100601 0.023343 1.464859492 0.002920262 0.031058352 0.561219926 −0.833361863
94 Analyte 95 0 6.23356,0 9 322 0.091050422 0.141299 1.335935817 0.013050372 0.037944549 0.644383212 −0.634009188
96 Analyte 97 0 6.25607,0 9 221 0.273334486 0.505144 1.382718281 0.018461158 0.043496426 0.541101922 −0.88602773
97 Analyte 98 0 6.26304,0 9 267 0.052183801 0.081353 1.339044648 0.021887851 0.047281114 0.641446738 −0.640598617
98 Analyte 99 0 6.28007,0 9 152 1.243281284 1.731247 1.362450345 0.018110888 0.04307052 0.718142143 −0.477658667
100 Analyte 101 0 6.35356,0 9 211 0.149975112 0.243234 1.269434425 0.034442556 0.057025121 0.6165884 −0.697620347
101 Analyte 102 0 6.37207,0 9 221 0.126068615 0.229719 1.369812092 0.014918915 0.039633839 0.548793895 −0.865663663
112 Analyte 114 0 6.51,0 3 207 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
124 Analyte 126 0 6.667,0 4 159 0.005980118 0.035398 1.206743852 0.007595819 0.031058352 0.168941731 −2.565402355
132 Analyte 134 0 6.76096,0 9 102 0.087156126 0.13135 1.424413383 0.004694475 0.031058352 0.663543315 −0.591737451
135 Analyte 137 0 6.83089,0 9 108 0.197475333 0.322281 1.394014594 0.009483719 0.033640096 0.612743258 −0.70664539
138 Analyte 140 0 6.86778,0 9 319 1.873157639 3.114122 1.418362299 0.007847303 0.031058352 0.601504164 −0.73335337
147 Analyte 149 0 7.02956,0 9 299 230.5117654 328.7347 1.368501132 0.014450612 0.039238447 0.70120909 −0.512083397
150 Analyte 152 0 7.08911,0 3 108 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
168 Analyte 170 0 7.36319,0 9 221 0.038675613 0.064306 1.425299204 0.003779737 0.031058352 0.601426746 −0.733539068
174 Analyte 176 0 7.44822,0 3 174 0.000258002 0.000388 1.382297717 0.007898488 0.031058352 0.664566179 −0.589515221
176 Analyte 178 0 7.4663,0 9 300 0.14066929 0.25431 1.397799484 0.009390264 0.033501999 0.553141309 −0.854280007
183 Analyte 185 0 7.57178,0 9 241 0.034659852 0.05353 1.278909492 0.022639121 0.048028239 0.647485316 −0.62708062
188 Analyte 190 0 7.65457,0 7 152 0.007184055 0.027339 1.117506783 0.048028223 0.066091974 0.262776377 −1.92809251
210 Analyte 212 0 8.07785,0 9 327 0.058009466 0.101589 1.381321063 0.008796901 0.032586355 0.571020535 −0.808385465
213 Analyte 215 0 8.15637,0 9 302 0.064257101 0.098722 1.246277713 0.028098654 0.052746433 0.650889175 −0.619516174
215 Analyte 217 0 8.16556,0 9 281 0.039345122 0.080491 1.374905261 0.003686217 0.031058352 0.48881664 −1.032634697
227 Analyte 229 0 8.36156,0 9 341 0.052448759 0.086946 1.325218816 0.017092886 0.041786174 0.603232561 −0.72921379
229 Analyte 231 0 8.40367,0 8 100 0.203180031 0.32939 1.341979958 0.013693148 0.038560536 0.616837794 −0.697036932
237 Analyte 240 0 8.54081,0 9 337 0.25036522 0.455655 1.366777246 0.036832395 0.058732065 0.549461995 −0.863908397
253 Analyte 256 0 8.70644,0 9 292 0.357528929 0.515931 1.21938121 0.048453083 0.066353391 0.692978537 −0.529117425
256 Analyte 259 0 8.74333,0 8 245 0.048845708 0.090829 1.326629434 0.009723922 0.033987829 0.537777275 −0.894919303
259 Analyte 262 0 8.78319,0 9 263 0.13088251 0.231069 1.344860566 0.044434442 0.063774445 0.566422421 −0.820049721
267 Analyte 270 0 8.88467,0 9 71 0.11227297 0.204138 1.433063266 0.00608667 0.031058352 0.549984911 −0.862536055
345 Analyte 350 0 10.0673,0 5 292 0.000258002 0.063722 1.539628212 0.004952684 0.031058352 0.004048846 −7.948273624
364 Analyte 369 0 10.4758,0 3 55 0.000258002 0.063552 1.542224923 0.016254112 0.040672706 0.004059669 −7.944422022
393 Analyte 400 0 11.1802,0 6 217 0.061713649 0.161587 1.405655109 0.013522845 0.038401138 0.38192255 −1.38864799
435 Analyte 442 0 12.219,0 4 67 0.005692675 0.030499 1.184497207 0.039424771 0.060446736 0.186653558 −2.421565088
455 Analyte 463 0 12.8955,0 9 232 3.442379815 4.609231 1.359547429 0.025385868 0.050546071 0.746844736 −0.421119747
487 Analyte 495 0 13.9389,0 6 259 0.013690852 0.027019 1.401570503 0.023138199 0.048509945 0.506703381 −0.98078664
503 Analyte 511 0 15.8464,0 9 357 0.080572597 0.145165 1.270859236 0.035617861 0.057880623 0.555041297 −0.849332977
ID The unique data number of the substance in this qualitative analysis
Peak The name of the substance obtained by qualitative analysis
Similarity The matching degree between the substance and the substance in the standard library in qualitative analysis, and the value is [0, 1000]
rt Chromatographic retention time of the substance
Count The number of times the substance was detected in all experimental groups
Mass Material characteristics Mass charge ratio of ions
MEAN OO The mean of the relative quantitative value of the substance in one of the experimental groups within the group comparison
MEAN XX The mean of the relative quantitative value of the substance in the other experimental group within the group comparison
VIP The substance in the group was compared to the OPLS-DAmodel obtained by the variable projection significance
P-value The p-value obtained by the t-test of this substance in the group comparison, p-value = probability of hypothesis being correct but rejected = number of negative results/total number of results, is a test probability against the sample data
Q-value The hypothesis test statistic (p-value) is the result after the correction of multiple hypothesis test. Q-value = the probability of being rejected but correct = the number of false-positive results/the number of presumed positive results. It is a test probability of the inference obtained from statistical test and the re-statistics of p-value
FOLD CHANGE The substance in this group was compared with the multiple relationship between the two groups of experiments
LOG_FOLDCHANGE FOLD CHANGE takes the logarithm base 2