Table 2.
Abbreviated list of medications and their safety profile for use in patients with Brugada syndrome.
| Avoided or preferably avoided [37] | Drug-induced Brugada syndrome [38] | Potentially safe [39] |
|---|---|---|
| Antiemetics | Antihistamines | Antiemetics |
| Metoclopramide | Diphenhydramine | Dexamethasone [24] |
| Prochlorperazine | Terfenadine | Droperidol |
| Ondansetron [24] | ||
| Antiarrhythmics | Miscellaneous | Analgesics |
| Flecainide | Alcohol | Ketorolac |
| Procainamid | Acetylcholine | Opioids |
| Propafenone | Cocaine | |
| Propofol [31, 40, 41] | ||
| Local anesthetics | Selective serotonin | Anesthetics |
| Bupivacaine | Reuptake inhibitors | Nitrous oxide |
| Lidocaine | Fluoxetine | Neuromuscular blockers |
| Procaine | Paroxetine | Reversal agents (e.g., Neostigmine/Glycopyrrolate, Sugammadex) |
| Miscellaneous | Thiopental Volatile agents (e.g., Desflurane, Isoflurane, Sevoflurane) | |
| Cannabis | Volatile agents (e.g., Desflurane, Isoflurane, Sevoflurane) | |
| Ketamine [32] | ||
| Oxcarbazepine | ||
| Tramadol | ||
| Psychotropics | Tricyclic antidepressants | Sedatives |
| Amitriptyline | Doxepin | Midazolam |
| Clomipramine | Imipramine | |
| Lithium | ||
| Loxapine | ||
| Nortriptyline | ||
| Trifluoperazine | ||
| Uterotonics | ||
| Methylergonovine |