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Melatonin improves (a) MDA, (b) CAT, (c) GPX, and (d) SOD levels in the PFC of MTX-induced rats. ##p < 0.01 and ###p < 0.001 vs. the vehicle group. ∗p < 0.05 and ∗∗∗p < 0.001 vs. the MTX group. MDA: malondialdehyde; CAT: catalase; GPX: glutathione peroxidase; SOD: superoxide dismutase.
