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Melatonin enhances (a) Nrf2 and (b) BDNF protein levels in the PFC of MTX-induced rats. ##p < 0.01 vs. the vehicle group. ∗p < 0.05 and ∗∗∗p < 0.001 vs. the MTX group. Nrf2: nuclear factor erythroid 2-related factor 2; BDNF: brain-derived neurotrophic factor.
