Table 2.
Effect of IHT and ACZ on hematological parameters of extreme hypoxia exposed rats at 8% FiO2. Rats were pretreated with acetazolamide and subjected to intermittent hypoxia training at 12% FiO2 followed by validation at 8% FiO2. Values are mean ± SD (n = 5). WBC (White Blood Cell), LYM % (Lymphocyte), MON% (Monocyte), NEU% (Neutrophil), RBC (Red Blood Cell), HB (Hemoglobin), HCT% (Hematocrit %), MCV (Mean Corpuscular Volume), PLT (Platelet), Retic (Reticulocyte %), Retic-ABS (Absolute reticulocyte count), NRBC (Nucleated RBC). Ns, Non-significant difference.
| Parameters | N | IHT + EH | IHT + ACZ + EH | ACZ + EH | EH | Level of Significance |
|---|---|---|---|---|---|---|
| WBC | 10.20 ± 2.13 | 12.20 ± 2.66 | 11.12 ± 1.66 | 12.60 ± 2.15 | 17.15 ± 2.00 | ≤0.0001 |
| LYM % | 73.51 ± 7.78 | 81.13 ± 13.04 | 78.70 ± 7.62 | 76.48 ± 11.16 | 93.16 ± 5.36 | ≤0.05 |
| MON % | 3.34 ± 1.32 | 5.55 ± 1.38 | 6.12 ± 2.46 | 5.82 ± 1.97 | 6.78 ± 1.41 | ns |
| NEU % | 17.43 ± 7.98 | 39.85 ± 19.38 | 22.38 ± 8.85 | 36.19 ± 16.54 | 54.67 ± 12.07 | ≤0.05 |
| RBC 106/ul | 6.83 ± 0.96 | 8.83 ± 0.31 | 7.27 ± 0.65 | 8.35 ± 0.34 | 11.56 ± 0.75 | ≤0.0001 |
| HB g/dL | 10.67 ± 0.90 | 15.21 ± 0.80 | 15.19 ± 0.67 | 16.83 ± 0.39 | 19.21 ± 1.43 | ≤0.0001 |
| HCT % | 34.07 ± 5.53 | 37.22 ± 2.34 | 40.25 ± 3.99 | 48.56 ± 1.24 | 63.92 ± 4.18 | ≤0.0001 |
| MCV fL | 55.82 ± 1.48 | 64.43 ± 1.38 | 55.43 ± 1.66 | 58.22 ± 1.43 | 88.13 ± 1.19 | ≤0.0001 |
| PLT 103/ul | 554.79 ± 107.46 | 678.52 ± 84.44 | 816.16 ± 160.80 | 988.50 ± 129.38 | 1092.20 ± 71.09 | ≤0.0001 |
| Retic % | 8.41 ± 1.04 | 13.77 ± 2.71 | 10.25 ± 3.79 | 13.34 ± 6.07 | 19.21 ± 4.75 | ≤0.05 |
| Retic-ABS 10^9/L | 530.07 ± 54.89 | 938.91 ± 177.94 | 784.91 ± 284.34 | 943.19 ± 337.36 | 1473.63 ± 475.10 | ≤0.05 |
| NRBC % | 2.46 ± 9.16 | 47.83 ± 27.34 | 36.57 ± 17.66 | 55.61 ± 21.88 | 89.05 ± 33.23 | ≤0.001 |
*p < 0.05, #p < 0.001, $p < 0.0001.