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. 2022 May 25;28(7):1461–1467. doi: 10.1038/s41591-022-01840-0

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (A) Breakthrough SARS-CoV-2 infection compared to the contemporary control (n=4,983,491) in non-immunocompromised (n=27,431) and immunocompromised (n=6,509) individuals. (B) A within breakthrough SARS-CoV-2 infection comparison between immunocompromised (n=6,509) and non-immunocompromised (n=27,431) individuals. Incident outcomes were assessed from 30 days after the positive SARS-CoV-2 test to end of follow-up. Adjusted hazard ratios (dots) and 95% confidence intervals (error bars) are presented, as are estimated excess burden (bars) and 95% confidence intervals (error bars). Burdens are presented per 1000 persons at 6 months of follow-up.