Figure 1.

Expression pattern of two types of tRDFs in LUAD

(A) The structure of tRNA and each fragment derived from tRNA, including upstream sequence (orange), downstream sequence (green), 5ʹ-tRF (blue), and 3ʹ-tRF (purple). (B) Composition of each type of tRDFs in each dataset is shown. (C) Composition of tRDFs from different tRNA sections in each subtype among all datasets is shown. (D) Venn plot shows 152 tRDFs were identified as common in three GEO adenocarcinoma cohorts and TCGA-LUAD cohort. (E) Clustering analysis from t-SNE of overall cohorts is shown. The cluster of GEO: GSE110907 was separated from the rest of cohorts shown in orange color and named as cluster A; cluster B is shown in blue. (F) Heatmap and hierarchical clustering shows the landscape of each type of tRDF expression in each group; tRDFs were classified into four subtypes as 5P/upstream sequences, 5ʹ-tRF, 3ʹ-tRF, and 3P/downstream sequences.