Figure 6.

tRDFs-correlated genes enrichment analysis

(A) Volcano plot showed 5,782 genes that correlated with 52 tRDFs; FDR < 0.05 and log2 fold change > 1 on the two sides were considered as statistically significant. (B) Thirteen KEGG pathways from GSEA that were identified common in the signaling pathways that miRNA target genes enriched in are shown. (C) The mutation frequency of top 25 genes from 653 DE-correlated candidate genes in 464 LUAD patients from the TCGA cohort; each column represents individual patients. The number on the right indicates the mutation frequency in each correlated gene. The right bar shows the proportion of each variant type, and the stacked bar graph below exhibited the fraction of conversions in each patient. (D) The six signaling pathways enriched from 657 genes that were correlated with six tRDF signatures are shown. (E) The network presents 31 gene targets in six signaling pathways with mutation frequency that correlated with three tRDF signatures.