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. 2022 Jul 22;13:4228. doi: 10.1038/s41467-022-31879-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Top 10 differentially expressed genes in major tissues (avg_log2FC: log fold-change of the average expression between neotenic axolotls and metamorphosed axolotls, avg_log2FC > 0: upregulated genes in neotenic axolotls, avg_log2FC < 0: upregulated genes in metamorphosed axolotls). b Gene ontology enrichment of differentially expressed genes in a (negative_log10_of_adjusted_p_value: −log 10 scale of p values, rich factor > 0: function enrichment of upregulated genes in neotenic axolotls with avg_log2FC > 0, rich factor < 0: function enrichment of upregulated genes in metamorphosed axolotls with avg_log2FC < 0, p values were calculated by the hypergeometric distribution, statistical test is one-sided, adjustments p values were made after p value is corrected by Benjamin & Hochberg multiple test).