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. 2022 Jul 22;13:4228. doi: 10.1038/s41467-022-31879-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Gene regulatory networks of neotenic axolotls and metamorphosed axolotls. Nodes represent network genes, and edges represent putative relationships. The size of nodes represents PageRank centralities. Calculated clusters are colored, and cell-type annotations are highlighted. Polygon shape covered annotated major cell types. b Same gene regulatory networks with the top 50 nodes ranked by PageRank centrality in the neotenic axolotl network and the top 100 nodes ranked by PageRank centrality in the metamorphosed axolotl network. Top nodes were highlighted in red. c Selected gene ontology (GO) enrichments of the top 100 differential PageRank centrality ranked nodes in the neotenic axolotl network and metamorphosed axolotl network (p values was calculated by the hypergeometric distribution, statistical test is one-sided, adjustments p values were made after p value is corrected by Benjamin & Hochberg multiple test).