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. 2022 Jul 22;8:93. doi: 10.1038/s41531-022-00357-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Number of studies that reported the identification of different aSyn PTMs in RBCs. b Variability of pS129 levels across the different studies comparing PD to HC or to patients with other synucleinopathies such as MSA. In this graph, it is also depicted that RBC pS129 levels differ between the membrane and cytosol fractions¹⁴⁹. Each dot represents the mean levels of pS129 aSyn reported in each study. The levels of aSyn PTMs such as nY39, pY125, AGEs or SUMOylation are not depicted in the figure because they were assessed only by dot and Western blotting analysis¹⁴⁶; no assay for obtaining an “absolute” quantification was carried out. The legend/color code in a corresponds also to b.