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. 2022 Jul 22;13:4237. doi: 10.1038/s41467-022-31103-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a. Insulin secretion in INS-1 832/13 cells at indicated glucose concentration in the absence (black) or presence (red) of GsMTx4 (2.5 μM) (n = 4), p values for the comparison between 2.8 and 16.7 mM G are <0.0001, 0.0018, p value for the comparison between Ctrl and GsMTx4 under 16.7 mM G is 0.0061. b As in a but in control cells (si-Ctrl) and after silencing of Piezo1 (si-Piezo1) (n = 4), p values for the comparison between 2.8 and 16.7 mM G are <0.0001, 0.0051, p value for the comparison between si-Ctrl and si-Piezo1 under 16.7 mM G is 0.0025. c Insulin secretion in INS-1 832/13 cells at indicated glucose concentration in the presence of DMSO (Ctrl), 25 µM yoda1, 200 µM diazoxide (DZX) or yoda1+DZX (n = 4), p values for the comparison between 2.8 and 16.7 mM G under Ctrl or yoda1 treatment are 0.0028, <0.0001, p values for the comparison between Ctrl and yoda1, Ctrl+DZX, yoda1+DZX under 16.7 mM G are 0.0155, 0.0035, 0.0062, respectively. d The average curve of insulin release measured by in situ pancreas perfusion with GsMTx4 from t=35 min to t=46 min as indicated (GsMTx4; n = 4). e As in d but perfuse without GsMTx4 (Ctrl; n = 3). f As in a but in human islets (n = 4), p value for the comparison between 2.8 and 16.7 mM G in Ctrl is 0.015, that for the comparison between Ctrl and GsMTx4 under 16.7 mM G is 0.0039. Data are presented as dot plots with mean values ± SEM. Statistical significances were evaluated by two-way ANOVA multiple comparisons in a, b, c, f. *, the significance compared between 2.8 mM and 16.7 mM glucose, #, the significance compared between treatments with and without pharmacological drugs. All statistical tests used were two-sided unless otherwise indicated. *p < 0.05, **p < 0.01, ****p < 0.0001, ^#p <0.05, ^##p < 0.01, ns not significant.