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. 2022 Jul 22;12:12557. doi: 10.1038/s41598-022-16188-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(I) Confocal laser scanning micrographs (CLSMs), obtained after 8 h following the application of Rhodamine B dye aqueous solution (A), Rhodamine B dye-loaded PNE 3 (B), and Rhodamine B dye-loaded PNE 3 gel (C), (II) The plot of the amount of SAH deposited per unit area in rat skin after the application of SAH, PNE 3, and PNE 3 gel, and (III) Histopathological photomicrographs of skin tolerance study; showing histopathological sections (hematoxylin- and eosin-stained) of (a) Untreated rat’s skin (group A); showing a normal histological structure of the epidermis and the skin appendages, and (b) Rat’s skin treated with SAH-loaded PNE 3 gel (group B) showing an apparent normal architecture of the epidermis and the dermis at 50 µm.