Table 1.
Fold up (“+”)- or down (“-”)-regulation of bone-regulating mRNA transcripts in JAK2V617F MKs vs. WT MKs. mRNAs with a JAK2V617F/WT ratio ≥4 are included. (Sec) denotes a secreted protein.
| mRNA | Fold up- or down-regulation in JAK2V617F/WT | Inhibitory (I) or Stimulatory (S) effect on Bone development (reference) |
|---|---|---|
| Ahsg (Alpha-2-HS-glycoprotein) | +8.66 (Sec) | I (36–39) |
| Alpl (Alkaline phosphatase liver/bone/kidney) | -22.81 | S (40, 41) |
| Chrd (Chordin) | +10.47 (Sec) | I (42, 43) |
| Col3a1 (Collagen, type III, alpha 1) | -4.06 (Sec) | S (44, 45) |
| Col4a1 (Collagen, type IV, alpha 1) | +6.58 (Sec) | possibly I (46–49) |
| Col14a1 (Collagen, type XIV, alpha 1) | +6.50 (Sec) | not known |
| Dlx5 (Distal-less homeobox 5) | -4.25 | S (50, 51) |
| Nog (Noggin) | +19.85 (Sec) | I (52, 53) |
| Sost (Sclerostin) | -4.30 (Sec) | I (54) |
| Vcam1 (Vascular cell adhesion molecule 1) | -7.45 | possibly S (55–57) |