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. 2022 Jul 21;32:100820. doi: 10.1016/j.neo.2022.100820

Fig. 3.

Fig. 3

The miR-17-92 expression signature is enriched in adenomas with 13q gain and in cancers versus adenomas.A) GSEA using the miR-17-92 expression signature in 26 adenoma tissue samples and 24 colorectal cancers (NES 1.73, FDR q value 0.0). B) ssGSEA enrichment score for the same samples (p-value 2.9x10-9). C) Hierarchical clustering of the differential mRNAs that compose the miR-17-92 expression signature in 26 adenoma tissue samples (blue in first row) and 24 colorectal cancers (pink in first row). The samples cluster independent of the presence of a 13q gain (black in second row). D) GSEA using the miR-17-92 expression signature in 18 adenoma tissue samples without 13q gain and 8 adenomas with 13q gain (NES 2.13, FDR q value 0.0). E) ssGSEA enrichment score for the same samples (p-value 0.062).