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. 2022 Jun 15;14(3):609–624. doi: 10.1016/j.jcmgh.2022.06.003

Figure 1.

Figure 1

(A) Schematic representation of experimental protocol 1. (B) (Left) Macroscopic view of the liver from c-Myc/h-Ras mice 14 weeks after hydrodynamic injection. (Right) Liver from mice subjected to hydrodynamic injection without oncogene-carrying plasmids. (C) (Left) Microscopic examination of c-Myc/h-Ras tumors (H&E, 5×). (Right) Microscopic examination of c-Myc/h-Ras tumors (H&E, 40×). (D) Nuclear staining of c-Myc in HCC (T) but not in the surrounding (S) liver (left: 5×, right: 10×). (E) Serial sections showing Ki-67–positive nuclear staining in HCC (T). S indicates surrounding liver (left: 5×, right: 10×).