Table 2.

Summary of Published Cases of Biopsy-Confirmed AA-Amyloid Kidney Disease in Patients With Familial Mediterranean Fever Treated With Tocilizumab and Reported Outcomes

Reference	Age (y)	Sex	Presentation	Tocilizumab Dose (mg/kg/mo)	Treatment Duration (mo)	Concurrent Treatment	Response
Serelis et al (2015)53	32	F	Nephrotic syndrome and 9.0 g/24 h proteinuria	8	2	Colchicine 1 mg, lisinopril 5 mg twice a day	Resolution of nephrotic syndrome, 3.0 g/24 h proteinuria
Ugurlu et al (2017)54	36	M	12 g/24 h proteinuria	8	6	None	Resolved nephrotic syndrome, 2.1 g/24 h proteinuria
	44	M	Baseline Cr 2.58 mg/dL, 23.7 g/24 h proteinuria	8	5	None	Cr 1.85 mg/dL and 14.9 g/24 h proteinuria
	45	M	Baseline Cr 1.28 mg/dL, 4.7 g/24 h proteinuria	8	31	None	Cr 1.12 mg/dL and 4.4 g/24 h proteinuria
	47	F	Baseline Cr 0.79 mg/dL, 2.1 g/24 h proteinuria	8	31	None	Cr 0.83 mg/dL and 1.4 g/24 h proteinuria
	23	M	Baseline Cr 0.69 mg/dL, 3 g/24 h proteinuria	8	4	None	Cr 0.71 mg/dL and 1.4 g/24 h proteinuria
	35	M	Baseline Cr 1.18 mg/dL, 1.7 g/24 h proteinuria	8	28	None	Cr 1.39 mg/dL and 2.7 g/24 h proteinuria
	41	F	Baseline Cr 0.71 mg/dL, 3 g/24 h proteinuria	8	13	None	Cr 0.64 mg/dL and 1.9 g/24 h proteinuria
	39	F	Baseline Cr 0.43 mg/dL, 1.6 g/24 h proteinuria	8	32	None	Cr 0.54 mg/dL and 0.7 g/24 h proteinuria
	24	F	Baseline Cr 0.4 mg/dL, 6 g/24 h proteinuria	8	4	None	Cr 0.35 mg/dL and 4.7 g/24 h proteinuria
	22	F	Baseline Cr 0.38 mg/dL, 1.8 g/24 h proteinuria	8	20	None	Cr 0.5 mg/dL and 0.1 g/24 h proteinuria
	45	F	Baseline Cr 0.79 mg/dL, 7.1 g/24 h proteinuria	8	6	None	Cr 0.93 mg/dL and 5.7 g/24 h proteinuria
	21	M	Baseline Cr 0.83 mg/dL, 11.7 g/24 h proteinuria	8	4	None	Cr 0.85 mg/dL and 16.7 g/24 h proteinuria

Abbreviations: AA, serum amyloid protein; Cr, creatinine; eGFR, estimated glomerular filtration rate; F, female, M, male.