Table 3.
Summary of Published Cases of Biopsy-Confirmed AA-Amyloid Kidney Disease in Patients Without Rheumatoid Arthritis or Familial Mediterranean Fever Treated With Tocilizumab and Reported Outcomes
| Reference | Age (y) | Sex | Associated Condition | Presentation | Tocilizumab Dose | Duration (mo) | Concurrent Treatment | Response |
|---|---|---|---|---|---|---|---|---|
| Magro-Checa et al (2011)43 | 25 | M | Latent tuberculosis | Nephrotic syndrome (18 g/24 h proteinuria) | 8 mg/kg/mo | 12 | Isoniazid 300 mg | Improved proteinuria to 1.7 g/24 h. Unchanged colonic amyloid deposition on repeat biopsy (12 mo) |
| De La Torre et al (2011)55 | 14 | F | Juvenile idiopathic arthritis | Nephrotic syndrome (7 g/24 h proteinuria) | 8 mg/kg/2 wk | 12 | None | Improved proteinuria and kidney function |
| Hočevar et al (2013)56 | 33 | M | Polyarteritis nodosa | 3.6 g/24 h proteinuria | 8 mg/kg/mo | 10 | Methylprednisolone 4 mg | Improvement in proteinuria to 1.0 g/24 h, regression of glomerular amyloid depositions on repeat biopsy at 6 mo |
| Redondo- Pachón et al (2013)57 | 51 | F | Bechets | Nephrotic syndrome (9.5 g/24 h proteinuria) | 8 mg/kg/mo | 12 | Colchicine 1 mg/d + isoniazid | Resolved nephrotic syndrome, improvement in proteinuria to 1.7 g/24 h |
| Pelegrin et al (2016)58 | 58 | F | Seronegative polyarthritis | Nephrotic syndrome (11 g/24 h proteinuria) | 480 mg/mo | 60 | None | Resolved nephrotic syndrome, stabilized eGFR |
| 46 | M | Chronic osteomyelitis | Nephrotic syndrome (6 g/24 h proteinuria) | 8 mg/kg/mo | 8 | None | Progression to kidney failure, increase to 11 g/24 h proteinuria | |
| 56 | F | Systemic sclerosis | Nephrotic syndrome (3 g/24 h proteinuria) | 8 mg/kg/mo | 5 | None | Stable eGFR, progression to 6 g/24 h proteinuria | |
| Ugurlu et al (2017)54 | 25 | M | Latent tuberculosis | Nephrotic syndrome (18 g/24 h proteinuria) | 8 mg/kg/mo | 12 | Isoniazid 300 mg | Improved proteinuria to 1.7 g/24 h, resolved nephrotic syndrome |
| Eriksson et al (2021)59 | 60 | M | AS | 0.52 g/24 h proteinuria | 8 mg/kg/mo | 52 | None | Stability |
| 69 | M | AS | urinary albumin-creatinine ratio 913 g/mol | 8 mg/kg/mo | 18 | None | Stability, decreased protein | |
| Giannese et al (2021)60 | 63 | M | Sweet syndrome | 10 g/24 h proteinuria | 8 mg/kg/mo | 23 | None | Complete resolution of nephrotic syndrome, 1.5 g/24 h proteinuria |
Abbreviations: AA, serum amyloid A protein; AS, ankylosing spondylitis; eGFR, estimated glomerular filtration rate; F, female; M, male.