Table 2.

Ongoing clinical trials to elucidate the effect of androgens and androgen blockade on immunity

Trial ID	Title	Comment
NCT04624828	Pilot Study of Immune Response Evaluation in Oligorecurrent and Oligoprogressive Prostate Cancer Patients Treated With Metastases-directed Stereotactic Body Radiation Therapy (SBRT) With and Without Concomitant Androgen Deprivation Therapy (IOSCAR)	Will monitor the dynamics of innate (monocytes, neutrophils, NK cells) and adaptive (T cells, B cells) immune cell subsets in the peripheral blood with flow cytometry before and after SBRT +/− ADT
NCT03654638	The Effect of a Soy Bread Diet Intervention on Immune Function in Men with Prostate Cancer	Will compare effect of soy bread vs wheat bread on immune function when starting ADT for prostate cancer. Peripheral blood MDSCs, cytokines, and T cell proliferation will be measured
NCT03344211	Immune Activation and Cellular Response from Enzalutamide Alone or With Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer	One of the primary objectives is to evaluate the immune activation of enzalutamide +/− radium-223
NCT03649841	Radiation Enhancement of Local and Systemic Anti-Prostate Cancer Immune Responses	A phase II trial of ADT + abiraterone +/− neutron radiation therapy. The primary outcome is the change in peripheral blood effector T cells from pre- to post-treatment
NCT04384835	Analysis of Sexual Bias in Type 2 Innate Lymphoid Cells (ILC2) in Asthmatic Patients: Role of Androgens	Will compare the proportion of ILC2 in blood between males and females with asthma. Plan to expand ILC2 in vitro and expose to AR antagonist or agonist