Table 3.

The risk of all-grade and grade 3-5 myocarditis, arrhythmia and hypertension.

Treatment Regimen			PD-1/PD-L1 VS Placebo	PD-1/PD-L1 VS Chemotherapy	PD-1/PD-L1 +Chemotherapy VS Chemotherapy	PD-1 +Chemotherapy VS Chemotherapy	PD-L1 +Chemotherapy VS Chemotherapy
Hypertension	Grade 3-5	P value	N/A	0.53	0.01	0.03	0.13
		95%CI		0.43-1.54	1.10-2.15	1.08-3.73	0.92-2.04
		OR		0.81	1.54	2.01	1.37
	All grade	P value	N/A	0.86	0.04	0.01	0.29
		95%CI		0.57-1.98	1.02-1.77	1.17-4.00	0.87-1.61
		OR		1.06	1.34	2.17	1.18
Arrhythmia	Grade 3-5	P value		0.06	0.23	0.51	0.32
		95%CI	N/A	0.94-7.35	0.76-3.13	0.45-4.99	0.65-3.77
		OR		2.63	1.54	1.50	1.56
	All grade	P value	0.39	0.10	0.02	0.63	0.02
		95%CI	0.47-7.18	0.84-6.08	1.07-2.46	0.52-3.01	1.09-2.80
		OR	1.83	2.27	1.63	1.24	1.75
Myocarditis	Grade 3-5	P value		0.08	0.18	0.14	0.97
		95%CI	N/A	0.87-11.49	0.68-8.06	0.70-11.95	0.06-15.12
		OR		3.16	2.34	2.88	0.94
	All grade	P value	0.33	0.06	0.10	0.08	0.97
		95%CI	0.50-8.04	0.97-12.49	0.83-9.37	0.87-14.15	0.06-15.12
		OR	2.01	3.48	2.79	3.51	0.94

N/A, No Available.