Comparison 1. PRP versus standard care (with/without placebo).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Chronic wounds completely healed	8	391	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.95, 1.50]
1.1 Diabetic foot ulcers	2	189	Risk Ratio (M‐H, Random, 95% CI)	1.22 [1.01, 1.49]
1.2 Venous leg ulcers	2	101	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.81, 1.27]
1.3 Mixed chronic wounds	4	101	Risk Ratio (M‐H, Random, 95% CI)	1.85 [0.76, 4.51]
2 Total area epithelialised (cm2)	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Mixed chronic wounds	3	66	Mean Difference (IV, Random, 95% CI)	‐2.78 [‐8.67, 3.11]
3 Percentage of wound area healed	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 Mixed chronic wounds	2	38	Mean Difference (IV, Random, 95% CI)	51.78 [32.70, 70.86]
4 Wound complications	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Infection	2	30	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.14, 4.73]
4.2 Dermatitis	2	87	Risk Ratio (M‐H, Random, 95% CI)	1.31 [0.18, 9.69]
5 Adverse events	3	102	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.29, 3.88]
5.1 Diabetic foot ulcers	1	72	Risk Ratio (M‐H, Random, 95% CI)	0.8 [0.05, 12.30]
5.2 Venous leg ulcers	1	15	Risk Ratio (M‐H, Random, 95% CI)	2.63 [0.35, 19.85]
5.3 Mixed chronic wounds	1	15	Risk Ratio (M‐H, Random, 95% CI)	0.44 [0.05, 3.85]