Table 2.
Descriptive analysis for survivors with and without CKDa at 1 year (n = 236)
| Variable | No CKD (n = 190) | CKD (n = 46) | P-value |
|---|---|---|---|
| Age at transplant (years) | 54 (18–74) | 62 (43–74) | <0.001 |
| Female gender | 75 (39) | 26 (57) | 0.04 |
| Hypertension | 63 (33) | 23 (50) | 0.03 |
| Diabetes | 14 (7) | 8 (17) | 0.05 |
| Baseline albumin (g/L) | 39 (30–49) | 39 (32–44) | 0.18 |
| Length of initial hospitalization (days) | 28 (17–219) | 32 (22–75) | 0.04 |
| Conditioning regimen MAC RIC |
45 (24) 145 (76) |
5 (11) 41 (89) |
0.06 |
| AKI within 100 days post-transplant |
28 (15) | 16 (35) | 0.002 |
| AKI stage 1 2 3 |
72 (38) 20 (11) 7 (4) |
11 (24) 22 (48) 7 (15) |
0.002 |
| Recipient CMV positive | 142 (75) | 33 (72) | 0.68 |
| CMV viremia | 88 (46) | 25 (54) | 0.33 |
| BK viremia | 9 (5) | 4 (9) | 0.29 |
| TMA | 5 (3) | 1 (2) | 0.99 |
| VOD | 17 (9) | 8 (17) | 0.11 |
| GVHD prophylaxis regimen ATG-PTCy-CSA Other |
126 (66) 64 (34) |
29 (63) 17 (37) |
0.67 |
| aGVHD Grade 1–2 Grade 3–4 |
74 (76) 23 (24) |
23 (88) 3 (12) |
0.24 |
| cGVHD Mild Moderate to severe |
18 (9) 53 (28) |
5 (11) 15 (33) |
0.47 |
| Baseline creatinine (mg/dL) | 0.8 (0.6–1.2) | 0.9 (0.6–1.4) | <0.001 |
| Baseline eGFR (mL/min/1.73 m2) | 97 (61–143) | 77 (46–110) | <0.001 |
| eGFR at 100 days (mL/min/1.73 m2) | 94 (51–134) | 62 (34–99) | <0.001 |
| CKD at baselinea | 0 (0) | 6 (13) | <0.001 |
| CKD at 100 daysa | 4 (2) | 20 (43) | <0.001 |
| eGFR at 1 year (mL/min/1.73 m2) | 88 (61–131) | 50 (15–60) | <0.001 |
| 1 year eGFR slope (mL/min/1.73 m2) | –8.0 (–56.8 to 34.2) | –24.6 (–82.4 to 2.9) | <0.001 |
Values are expressed as frequency (%) or median (range). CKD = chronic kidney disease; MAC = myeloablative conditioning; RIC = reduced intensity regimen; AKI = acute kidney injury; CMV = cytomegalovirus; VOD = veno-occlusive disease; TMA = thrombotic microangiopathy; GVHD = graft-versus-host disease; ATG-PTCy-CSA = anti-thymocyte globulin with post-transplant cyclophosphamide and cyclosporine; aGVHD = acute graft-versus-host disease; cGVHD = chronic graft-versus-host disease; eGFR = estimated glomerular filtration rate; eGFR is calculated according to CKD-EPI equation.
aCKD is defined as eGFR < 60 mL/min/1.73 m2.