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. Author manuscript; available in PMC: 2022 Jul 23.
Published in final edited form as: Addict Biol. 2021 Feb 3;26(4):e13005. doi: 10.1111/adb.13005

FIGURE 2.

FIGURE 2

Effects of cannabinoids on optogenetic intracranial self-stimulation (oICSS) in dopamine transporter (DAT)-Cre mice. A, Cannabidiol (CBD) did not show significant effects on oICSS responding. B–D, WIN55,212-2, ACEA, and AM-2201 (respectively) dose-dependently shifted the oICSS curve downward. E, 5F-AMB did not show any significant effects at the current doses. F, XLR-11, at 1.0 mg/kg, significantly shifted the oICSS curve upward. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the vehicle control group