TABLE 1.
Cannabinoid receptor binding affinities of cannabinoids tested in this study
| Compound | CB1R Ki (nM) | CB2R Ki (nM) | CB1R/CB2R | Reference | Half life (T1/2) | oICSS effecta |
|---|---|---|---|---|---|---|
| Δ9-THC | 35.3 | 3.9 | 9.05 | 40 | ~92–108 min67 | ↓ |
| 39.5 | 40 | 0.99 | 41 | |||
|
| ||||||
| Cannabidiol | 4,350 | 2,860 | 1.52 | 42 | ~120 min 68 | No change |
|
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| ACEA | 1.4 | >2,000 | >0.0007 | 43 | N/A | ↓ |
|
| ||||||
| WIN55,212-2 | 9.94 | 16.2 | 0.613 | 40 | 24-36 h 69 | ↓ |
|
| ||||||
| XLR-11 | 24 | 2.1 | 11.4 | 44 | N/A | ↑ |
|
| ||||||
| 5F-AMB | 8.71 | 7.99 | 1.09 | 45 | N/A | No change |
|
| ||||||
| AM-2201 | 1.0 | 2.6 | 0.38 | 46 | 4-6 h 70 | ↓ |
Abbreviations: N/A, not available; oICSS, optogenetic intracranial self-stimulation.
a
The findings in the present study.