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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2022 May 27;15(6):e007956. doi: 10.1161/CIRCEP.121.007956

Table 6:

P-glycoprotein (P-gp) - Modulators – adopted from56, 108, 128, 163

P-gp modulators (Lund, Terrier, FDA website)
Inhibitor Inducer
Strong Inhibitor Cyclosporine Strong Inducer Carbamazepine
Dronedarone Rifampin
Ketoconazole St. John’s Wort167*
Itraconazole
Lapatinib
Ritonavir
Verapamil
Weak Inhibitor Amiodarone Weak Inducer Phenytoin
Carvedilol
Clarithromycin
Diltiazem
Eliglustat
Fluvoxamine
Maraviroc
Mirabegron
Paroxetine
Propafenone
Quinidine
Ranolazine
Simeprevir
Saquinavir
Ticagrelor
Tipranavir
Uncertain Inhibitor Carbozantinib
Enzlutamide
Erythromycin
Ibrutinib
Imatinib
Irbesartan
Ivermectin
Ledipasvir
Lomitapide
Loperamide
Meflokine
Ponatinib
Regorafenib
Simvastatin
Tacrolimus