REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Bcl2	BioLegend	Clone BCL/10C4
Pten	Cell Signaling	Cat#9188
β-actin	Sigma-Aldrich	Clone AC-15
A-RAF	Cell Signaling Technology	Cat#75804
B-RAF	Cell Signaling Technology	Cat#14814
C-RAF	Cell Signaling Technology	Cat#53745
KRAS	Abnova	Cat#H00003845-M01, clone 3B10-2F2
ɑ-tubulin	Sigma Aldrich	Cat#T6199
Rabbit anti-GFP	Cell Signaling	Cat#2956
Rabbit anti-Pten	Cell Signaling	Cat#9188
Mouse anti-β-catenin	BD Biosciences	Cat#610153
Anti-rabbit	Vector Laboratories	Cat#MP7401
Anti-mouse	Vector Laboratories	Cat#MP2400
Ex perimental models: Cell lines
293FT	Thermo Fisher Scientific	Cat#R70007; RRID:CVCL_6911
U-251	Sigma-Aldrich	Cat#09063001; RRID:CVCL_0021
NIH/3T3	ATCC	RRID:CVCL_0594
H2009	ATCC	Cat#CRL-5911; RRID: CVCL_1514
H1975	ATCC	Cat#CRL-5908; RRID:CVCL_1511
PC9	BIDMC	RRID:CVCL_B260
Experimental models: Organisms/strains
Female athymic nu/nu mice	The Jackson Laboratory	RRID:IMSR_JAX:002019
Female C57BL/6 mice	Harlan Laboratories	N/A
Oligonucleotides
Primers, shRNAs	See Table S1	N/A
Recombinant DNA
Plasmid: pCF806-reci (UT4GEPIR)	This paper (Table S1)	Addgene, pCF806-reci, Cat#186711
Plasmid: pCF806-shRen.713 (UT4GEPIR)	This paper (Table S1)	Addgene, pCF806-shRen.713, Cat#186712
Plasmid: pCF806-shABC1 (UT4GEPIR)	This paper (Table S1)	Addgene, pCF806-shABC1, Cat#186713
Plasmid: pCF806-shABC2 (UT4GEPIR)	This paper (Table S1)	Addgene, pCF806-shABC2, Cat#186714
Plasmid: LT3GEPIR	Fellmann et al. (2013)	N/A
Software and algorithms
SplashRNA algorithm to predict shRNA sequences	Pelossof et al. (2017)	http://splashrna.mskcc.org/