Table 3.

Mean absolute T cell counts of the SC and SN groups, at Visits A and B

T cell populationa	Visit Ab, Mean (SE) n			Visit Bc, Mean (SE) n
	SC	SN	p valued	SC	SN	p valued
CD4 T cells, cells/mm3	1088 (384) n = 93	1004 (428) n = 97	0.16	616 (240) n = 101	1000 (365) n = 93	< 0.001
CD8 T cells, cells/mm3	630 (252) n = 93	598 (287) n = 97	0.42	890 (402) n = 101	617 (295) n = 93	< 0.001
Naive (CD45RA+CCR7+) CD4 T cells, cells/mm3	404 (193) n = 92	406 (293) n = 96	0.95	244 (140) n = 101	383 (231) n = 92	< 0.001
Naive (CD45RA+CCR7+) CD8 T cells, cells/mm3	219 (116) n = 92	212 (130) n = 96	0.72	138 (82) n = 101	214 (113) n = 92	< 0.001
Activated (HLA-DR+CD38+) CD4 T cells, cells/mm3	28 (13) n = 90	27 (19) n = 95	0.63	32 (17) n = 99	28 (18) n = 90	0.14
Activated (HLA-DR+CD38+) CD8 T cells, cells/mm3	25 (16) n = 90	23 (20) n = 95	0.40	180 (149) n = 99	26 (30) n = 90	< 0.001
Senescent (CD28−CD57+) CD4 T cells, cells/mm3	45 (55) n = 92	33 (42) n = 96	0.10	39 (50) n = 101	33 (37) n = 92	0.34
Senescent (CD28−CD57+) CD8 T cells, cells/mm3	108 (81) n = 92	104 (88) n = 96	0.79	140 (115) n = 101	105 (105) n = 92	0.03

^aAbsolute CD4 and CD8 T cell counts obtained from MWCCS database, and were determined by standardized flow cytometry at the time of original blood sample collection; T cell subsets determined by multicolor flow cytometry at the time of thawing of viable PBMC aliquots as described in the STAR Methods, and absolute T cell subset counts calculated from total CD4 and CD8 counts (see also Table S4).

^bAll participants HIV-uninfected at Visit A, matched on age and hepatitis C status.

^cSC recently HIV-infected, SN persistently HIV-uninfected at matched time intervals at Visit B.

^dp values are for comparison of SC vs. SN at each visit by t-tests (p values in italics, bold if < 0.05).