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. 2022 Jul 23;13:336. doi: 10.1186/s13287-022-03015-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Overexpression mmu_circ_0001052 in ADSCs-derived exosomes promoted proliferation, migration and angiogenesis of high glucose-induced HUVECs. A the expression of miR-106a-5p and mmu_circ_0001052 in high glucose-induced HUVECs. B the transfection efficiency via fluorescence microscope. C the expression of mmu_circ_0001052 in ADSCs transfected with different vectors (exosomes in exo group was extracted from normal ADSCs, these in exo+oe-vector group from ADSCs transfected with empty vector, and these in exo+oe-mmu_circ_0001052 group from ADSCs transfected with oe-mmu_circ_0001052). D the fusion of exosomes into cells via immunofluorescence. E apoptosis by flow cytometry. F proliferation by MTT. G migration by transwell. H angiogenesis via tube formation assay. All data were obtained from at least three replicate experiments. *P < 0.05, **P < 0.01. N = 3. One-way ANOVA was used to analyze the differences among groups. Afterward, post-pairwise comparison was conducted by Dunnett’s multiple comparison test. Comparison among multiple groups at different time points was analyzed by repeated measures ANOVA