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. 2022 Jul 22;41:229. doi: 10.1186/s13046-022-02437-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — DLAT enhances glycolysis metabolism in NSCLC cells. A DLAT overexpression increased L-lactate production in PC9 cells. B DLAT up-regulation enhanced L-lactate production in A549 cells. C DLAT overexpression increased pyruvate release from PC9 cells. D Up-regulation of DLAT promoted pyruvate release from A549 cells. E Knockdown of DLAT suppressed L-lactate generation from PC9 cells. F Down-regulation of DLAT inhibited L-lactate generation from A549 cells. G Inhibition of DLAT expression decreased pyruvate production in PC9 cells. H Decreased DLAT expression reduced pyruvate production in A549 cells. I Overexpression of DLAT enhanced ECAR levels in PC9 cells. J Up-regulation of DLAT increased ECAR levels in A549 cells. *P < 0.05, **P < 0.01