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. 2022 Jul 22;16:24. doi: 10.1186/s40246-022-00399-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Contribution of alternative TSSs to acute-stress-induced transcriptome response and their functional role. A. Number of differentially expressed genes (DEGs) relative to pre-exercise and their overlap at different time points after acute exercise. Up- and down-regulated genes are shown in red and blue, respectively; the number of time-specific DEGs is underlined. B. Principal component analysis shows the consistency of gene responses in different volunteers at different time points during the first hours after acute exercise. C. Number of DEGs having one (532 genes) or several (733 and 146 genes) TSSs and showing differential TSSs usage (146 genes). Another set of genes (111 genes) shows differential TSSs usage without altering the overall expression of each gene. D. Examples of different TSS regulation patterns. E. Distribution of TSSs per gene and a potential functional role of the alternative TSSs