FIGURE 2.

CD36 and ERK5 promote arterial thrombosis in dyslipidemic conditions. (a) apoE null mice were lethally irradiated followed by transplantation of bone marrows from ERK5 expressing or platelet ERK5 deleted mice. The chimeric mice were allowed to recover from bone marrow transplantation before feeding control or high-fat diet for at least 6 weeks. Kaplan–Meier analyses of the ferric chloride-induced in-vivo thrombosis on the carotid artery with time to occlusion as the censored analysis. (b) Wild type C57Bl/6 or CD36 null mice at 8 weeks of age were fed control or high-fat diet for at least 6 weeks before performing laser-induced in-vivo arterial thrombosis on the cremasteric artery. Representative video microscopy images of platelet accumulation (in green) and fibrin accumulation (in red) in real time up to 5 min are shown. The arrows indicate direction of blood flow and the arrow on the side indicates the side of vessel injury. CD36, CD36.