Table 2.
Adverse events with oral treprostinil in SSc patients (n = 12)
| Event | No. of patients (%) | Mild | Moderate | Severe | Median (range) time to resolution, days |
|---|---|---|---|---|---|
| Headache | 7 (58) | 5 | 2 | 0 | 12 (1–90) |
| Abdominal pain | 6 (50) | 4 | 2 | 0 | 74 (3–134) |
| Diarrhoea | 5 (42) | 3 | 2 | 0 | 76 (3–143) |
| Nausea | 3 (25) | 2 | 1 | 0 | 38 (20–56) |
| Jaw pain | 2 (16) | 1 | 1 | 0 | 11 (1–20) |
| Dizziness | 1 (8) | 0 | 1 | 0 | 20 |
| Hypotensiona | 1 (8) | 1 | 0 | 0 | 2 |
| Epistaxis | 1 (8) | 1 | 0 | 0 | 2 |
| Weight loss | 1 (8) | 1 | 0 | 0 | 30 |
| Flushing | 1 (8) | 1 | 0 | 0 | 1 |
a
Defined as systolic blood pressure <90 mmHg or diastolic blood pressure <60 mmHg.