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. 2022 Apr 4;187(2):325–344. doi: 10.1093/toxsci/kfac037

Figure 5.

Figure 5.

Impact of the lack of wfikkn1 on the 48-h postfertilization zebrafish transcriptome. A, Top 10 MetaCore process network enrichments of human orthologs of differentially expressed genes between WT_DMSO and mut_DMSO. Significant processes (FDR-adjusted p < .05) are bolded and italicized. The interaction size is the number of observed genes from each cluster that belongs to the process network, and enrichment ratio is the ratio of the number of observed genes to the expected genes from each network. The top 2 processes are skeletal muscle development and muscle contraction. B, MetaCore interactome of genes enriched in the top 2 biological process networks (gray). AHR and WFIKKN1 were manually added to the network. Proteins predicted by MetaCore that interact with AHR or WFIKKN1, and the gray genes are depicted in other colors (BMP4, CTNNB1, AR, NANOG, SOX17, RUNX1, BMP2, and BMP4). Thicker colored lines show the direct interactions with WFIKKN1. Abbreviations: WT, wild type; DMSO, dimethyl sulfoxide; FDR, false discovery rate. AHR, aryl hydrocarbon receptor. A color version of this figure appears in the online version of this article.