TABLE 1.
Signalment, tumor characteristics, and signs of neurologic disease in the ITT population; comparison of the study population and the 2 treatment groups
| Total (n = 57) | Control [10 × 4 Gy] (n = 28) | SIB [10 × 4 Gy + 11% boost to the GTV] (n = 29) | |
|---|---|---|---|
| Age (years) a | 9.6 (3.4‐14.5) | 9.5 (3.4‐14.5) | 9.6 (5.8‐12.8) |
| Weight (kg) a | 17.4 (2.5‐40.8) | 15.6 (3.3‐40.8) | 23.0 (2.5‐40.0) |
| Sex | |||
| Female, intact | 3 (5%) | 2 (7%) | 1 (3%) |
| Female, spayed | 25 (44%) | 12 (43%) | 13 (45%) |
| Male, intact | 10 (18%) | 6 (21%) | 4 (14%) |
| Male, castrated | 19 (33%) | 8 (29%) | 11 (38%) |
| Breed and head conformance | |||
| Purebred | 44 (77%) | 20 (71%) | 24 (83%) |
| Mixed breed | 13 (23%) | 8 (29%) | 5 (17%) |
| Brachycephalic | 16 (28%) | 6 (21%) | 10 (34%) |
| Non‐brachycephalic | 41 (72%) | 22 (79%) | 19 (66%) |
| Tumor type and neuraxis | |||
| Extra‐axial | |||
| Meningioma | 28 (49%) | 13 (46%) | 15 (52%) |
| Pituitary tumor | 9 (16%) | 6 (21%) | 3 (10%) |
| Choroid plexus tumor | 4 (7%) | 1 (4%) | 3 (10%) |
| Intra‐axial | |||
| Glioma | 16 (28%) | 8 (29%) | 8 (28%) |
| Tumor location | |||
| Forebrain | 36 (63%) | 15 (54%) | 21 (72%) |
| Cerebellum | 3 (5%) | 1 (4%) | 2 (7%) |
| Brainstem | 9 (16%) | 6 (21%) | 3 (10%) |
| Pituitary | 9 (16%) | 6 (21%) | 3 (10%) |
| Rostral cranial fossa | 12 (21%) | 6 (21%) | 6 (21%) |
| Middle cranial fossa | 16 (28%) | 6 (21%) | 10 (34%) |
| Caudal cranial fossa | 12 (21%) | 7 (25%) | 5 (17%) |
| Overlapping | 17 (30%) | 9 (32%) | 8 (28%) |
| Sign of neurologic disease—severity before RT | |||
| No sign | 1 (2%) | 1 (4%) | 0 (0%) |
| Mild | 12 (21%) | 4 (14%) | 8 (28%) |
| Moderate | 8 (14%) | 5 (18%) | 3 (10%) |
| Severe | 14 (25%) | 9 (32%) | 5 (17%) |
| Seizures only | 22 (39%) | 9 (32%) | 13 (45%) |
| Sign of neurologic disease—category | |||
| Cranial nerve deficit(s) | 24 (42%) | 11 (39%) | 13 (45%) |
| Seizures | 31 (54%) | 14 (50%) | 17 (59%) |
| Isolated seizures | 14 (25%) | 7 (25%) | 7 (24%) |
| Cluster seizures | 16 (28%) | 6 (21%) | 10 (34%) |
| Status epilepticus | 1 (2%) | 1 (4%) | 0 (0%) |
| Ataxia | 23 (40%) | 16 (57%) | 7 (24%) |
| Paresis | 15 (26%) | 12 (43%) | 3 (10%) |
| GTV (cm3) a | 2.6 (0.2‐11.8) | 2.6 (0.2‐10.8) | 2.6 (0.3‐11.8) |
| Brain volume (cm3) a | 85.2 (46.9‐133.0) | 82.2 (57.0‐106.7) | 86.1 (46.9‐133.0) |
| GTV/brain volume (%) a | 3.2 (0.2‐10.8) | 3.3 (0.2‐10.6) | 3.2 (0.4‐10.8) |
| NTCP (%) a | 3.9 (0.1‐20.1) | 2.7 (0.1‐19.8) | 5.6 (0.8‐20.1) |
a
Values expressed as median and range.
Abbreviations: GTV, gross tumor volume; NTCP, normal tissue complication probability; RT, radiation therapy.