TABLE 7.
Agreement between thoracic radiograph interpretation (normal vs abnormal) and concentration of acute phase proteins (APP): C‐reactive protein (CRP), serum amyloid A (SAA), and haptoglobin at the different time points
| D1 | Agreement D1 | D7 | Agreement D7 | D14 | Agreement D14 | D28 | Agreement D28 | D60 | Agreement D60 | |
|---|---|---|---|---|---|---|---|---|---|---|
| TXR abnormal | 16/16 (100%) | ‐ | 10/14 (71%) | ‐ | 5/16 (31%) | ‐ | 3/16 (19%) | ‐ | 1/14 (7%) | ‐ |
| CRP abnormal | 14/16 (88%) | 88% | 6/14 (43%) | 43% | 3/16 (19%) | 75% | 1/16 (6%) | 75% | 0/14 (0%) | 93% |
| SAA abnormal | 15/16 (94%) | 94% | 7/14 (50%) | 64% | 1/16 (6%) | 75% | 1/16 (6%) | 75% | 3/14 (21%) | 93% |
| Haptoglobin abnormal | 9/16 (56%) | 56% | 10/14 (71%) | 57% | 10/16 (63%) | 44% | 8/16 (50%) | 44% | 0/14 (0%) | 74% |
| Any APP abnormal | 15/16 (94%) | 94% | 10/14 (71%) | 79% | 12/16 (75%) | 44% | 8/16 (50%) | 44% | 3/14 (21%) | 74% |
| CRP or SAA abnormal | 15/16 (94%) | 94% | 7/14 (50%) | 50% | 3/16 (19%) | 52% | 1/16 (6%) | 52% | 3/14 (21%) | 93% |
Note: Observed agreement was calculated using a 2 × 2 contingency table where radiographical reports were labeled as normal vs abnormal and APP concentration within reference interval (normal) or above reference interval (abnormal) using the formula observed agreement = (A + B/A + B + C + D) × 100, where A = number of dogs with normal radiographs with normal APP, B = number of dogs with abnormal radiographs with abnormal APP, C = number of dogs with normal thoracic radiographs and abnormal APP, and D = number of dogs with abnormal thoracic radiographs and normal APP.