Table 2.
Comparison of Existing Definitions of PHLF (n=1,646)
| Balzan | Mullen | ISGLS | ISGLS grades B&C |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Major Morbidity a | n=19 | 95% CI | n=68 | 95% CI | n=444 | 95% CI | n=159 | 95% CI | |
| Sensitivity | 1.77 | (0.58, 4.09) | 6.03 | (3.55, 9.48) | 41.49 | (35.68, 47.48) | 18.09 | (13.77, 23.08) | |
| Specificity | 98.97 | (98.28, 99.44) | 96.26 | (95.11, 97.20) | 76.03 | (73.67, 78.27) | 92.08 | (90.52, 93.46) | |
| PPV | 26.32 | (9.15, 51.20) | 25.00 | (15.29, 36.98) | 26.35 | (22.31, 30.71) | 32.01 | (27.60, 43.04) | |
| NPV | 82.97 | (81.06, 84.77) | 83.21 | (81.27, 85.02) | 86.27 | (84.20, 88.17) | 84.46 | (82.52, 86.27) | |
| OR | 1.74 | (0.62, 4.87) | 1.65 | (0.94, 2.90) | 2.25 | (1.72, 2.94) | 2.57 | (1.79, 3.69) | |
| AUC | 0.504 | 0.511 | 0.588 | 0.551 | |||||
| Mortality b | |||||||||
| Sensitivity | 12.50 | (5.88, 22.41) | 40.28 | (28.88, 52.50) | 69.44 | (57.47, 79.76) | 56.94 | (44.73, 68.57) | |
| Specificity | 99.37 | (98.83, 99.69) | 97.52 | (96.63, 98.23) | 74.97 | (72.75, 77.09) | 92.50 | (91.09, 93.76) | |
| PPV | 47.37 | (24.45, 71.14) | 42.65 | (30.72, 55.23) | 11.26 | (8.47, 14.58) | 25.79 | (19.18, 33.31) | |
| NPV | 96.13 | (95.07, 97.01) | 97.28 | (96.35, 98.02) | 98.17 | (97.24, 98.85) | 97.91 | (97.05, 98.58) | |
| OR | 22.34 | (8.77, 56.92) | 26.54 | (15.04, 46.85) | 6.81 | (4.07, 11.38) | 16.32 | (9.87, 26.98) | |
| AUC | 0.559 | 0.689 | 0.722 | 0.747 | |||||
a
Major morbidity is defined as highest Clavien-Dindo grade 3-4.
b
90-day all-cause mortality
PPV: positive predictive value; NPV: negative predictive value; OR: odds ratio; AUC: area under the ROC curve; CI: confidence interval