Table 5.
Multivariate analysis of clinicopathological characteristics associated with survival.
| Variable | Overall survival | ||
|---|---|---|---|
| HR | 95% CI | P | |
| Model 1 | |||
| CTC ≥ 20 | 2.285 | 1.073-4.869 | 0.032 |
| NLR ≥ 2.15 | 1.902 | 1.005-3.600 | 0.048 |
| AFP (≥400 ng/mL) | 0.910 | 0.466-1.777 | 0.783 |
| Tumor size (≥5 cm) | 1.820 | 0.612-5.416 | 0.282 |
| Tumor number (>1) | 0.510 | 0.192-1.351 | 0.175 |
| MVI (positive) | 4.179 | 1.369-12.756 | 0.012 |
| BCLC stage (B-C) | 4.988 | 1.430-17.401 | 0.012 |
| PVTT (positive) | 1.831 | 0.721-4.645 | 0.203 |
| Model 2 | |||
| CTC-NLR | 2.050 | 1.235-3.402 | 0.005 |
| AFP (≥400 ng/mL) | 0.884 | 0.461-1.695 | 0.710 |
| Tumor size (≥5 cm) | 1.831 | 0.617-5.433 | 0.276 |
| Tumor number (>1) | 0.530 | 0.205-1.374 | 0.192 |
| MVI (positive) | 4.237 | 1.393-12.887 | 0.011 |
| BCLC stage (B-C) | 4.865 | 1.402-16.877 | 0.013 |
| PVTT (positive) | 1.857 | 0.733-4.700 | 0.192 |
AFP: alpha-fetoprotein; ALB: albumin; CTC: circulating tumor cell count; NLR: neutrophil-lymphocyte ratio; BCLC stage: Barcelona Clinic Liver Cancer stage; MVI: microvascular invasion; PVTT: portal vein tumor thrombosis.