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. 2022 Jul 16;2022:4135752. doi: 10.1155/2022/4135752

Figure 5.

Figure 5

Taurine protects mitochondrial membrane integrity. Taurine treatment blocks the opening of mPTP in L02 cells caused by iron overload injury. (a) CaCl2 (200 μM) was added for 20 min, and absorbance was measured at a wavelength of A = 520 nm to indicate the opening of mPTP. (b) Calculating the opening of mPTP as OD = A5200min − A52020min. Taurine treatment blocks the transfer of Cyt c from mitochondria to the cytoplasm. (c, d) Cyt c protein level in the cytoplasm and mitochondria. (e) Histogram of Cyt c expression level in the cytoplasm. (f) Histogram of Cyt c expression level in the mitochondria. Data values are expressed as the mean ± standard error of the mean (SEM), n = 3. ∗∗P < 0.01 vs. the control group. ##P < 0.01 vs. the iron group. &&P < 0.01 vs. the iron+taurine group. &P < 0.05 vs. the iron+taurine group.