Table 4.
External validation of radiomic parameters performance in comparison between responders and non-responders by using receiver operating characteristic (ROC) curve
| Radiomic features | PFS 11 vs PFS > 11 | ||||
|---|---|---|---|---|---|
| Arterial phase | Sensitivity | Specificity | AUC | Criterion | P |
| First Order_10Percentile | 59% | 78% | 0.66 | > 49.9 | 0.0001 |
| First Order_Mean | 59% | 79% | 0.63 | > 65.5 | 0.002 |
| First Order_Median | 63% | 74% | 0.63 | > 64.9 | 0.002 |
| First Order_ RootMeanSquared | 66% | 74% | 0.67 | > 68.8 | < 0.0001 |
| GLCM_Correlation | 81% | 84% | 0.90 | > 0.21 | < 0.0001 |
| GLCM_Imc1 | 74% | 85% | 0.84 | ≤ 0.037 | < 0.0001 |
| GLCM_Imc2 | 45% | 97% | 0.74 | > 0.28 | < 0.0001 |
| GLCM_MCC | 68% | 97% | 0.82 | > 0.35 | < 0.0001 |
| GLSZM_LargeAreaLowGrayLevelEmphasis | 25% | 95% | 0.58 | ≤ 32,331.22 | 0.04 |
| Portal phase | |||||
| Shape_SurfaceVolumeRatio | 39% | 100% | 0.69 | > 0.07 | < 0.0001 |
Bold values denote statistical significance
*PFS Progression-free survival, AUC Area under the curve, GLCM Gray-level co-occurrence matrix, GLSZM Gray-level size zone matrix