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. Author manuscript; available in PMC: 2023 Jul 8.
Published in final edited form as: Circ Res. 2022 Jun 1;131(2):168–183. doi: 10.1161/CIRCRESAHA.121.319582

Figure 1. Effect of enhancing endothelial functions and NO production on systemic metabolism.

Figure 1.

(A&B) Body weight (A) and subcutaneous fat mass (B) in Wt and ECIRS1 mice in the absence or presence of L-NAME. (C&D) Representative and quantification of respiratory exchange rate (C) and heat generation (D) assessed by CLAMS analysis. (E) Representative and quantification of BAT mass. (F) Histological analysis of lipid droplet by H&E staining (J) and quantitation of capillary density (K) using anti-CD31antibody staining in BAT. (L) Vegf mRNA levels in BAT of all mice groups. Biological replicates n=8 for each group. P values were determined by Two-way ANOVA with Tukey’s multiple comparisons test in A, B, C, D, E and F. Data presented as mean ± SD; n=mice/group as indicated.