Table 4.
Change from Observed Baseline and Observed 12-months for the validation and development samples of robustly cognitively intact participants.
| Development Sample M12 – BL Δ | Validation Sample M12 – BL Δ | p value | Effect Size | |
|---|---|---|---|---|
| RAVLT | ||||
| Total Recall | 0.24 (7.9) | 0.46 (8.3) | .79 | −0.03 |
| Delayed Recall | 0.16 (3.5) | 0.44 (3.5) | .43 | −0.08 |
| Logical Memory | ||||
| Immediate Recall | 1.02 (3.3) | 0.86 (3.0) | .64 | 0.05 |
| Delayed Recall | 0.50 (3.4) | 0.32 (3.4) | .62 | 0.05 |
| ADAS-Cog | −0.38 (4.0) | −0.70 (3.5) | .41 | 0.09 |
| Clock Drawing | −0.03 (0.7) | −0.03 (0.7) | .49 | −0.07 |
| Clock Copy | 0.00 (0.6) | −0.01 (0.5) | .92 | 0.01 |
| DS Forward | 0.07 (1.7) | −0.02 (1.4) | .71 | 0.06 |
| DS Backward | 0.00 (1.7) | 0.11 (2.0) | .70 | −0.06 |
| Digit Symbol | 0.99 (5.0) | 1.60 (7.6) | .52 | −0.09 |
| Animal Fluency | 0.69 (4.5) | 0.20 (4.4) | .28 | 0.11 |
| Vegetable Fluency | 0.13 (3.4) | −0.27 (3.6) | .42 | 0.12 |
| TMT-A | −1.39 (8.6) | −1.78 (10.4) | .69 | 0.04 |
| TMT-B | −5.71 (39.4) | −0.28 (35.9) | .15 | −0.15 |
| BNT | 0.42 (1.4) | 0.53 (1.7) | .51 | −0.07 |
| MMSE | −0.11 (1.4) | −0.07 (1.5 | .83 | −0.02 |
| MOCA | 0.56 (2.4) | 0.19 (2.2) | .27 | 0.16 |
Note: M12 = Observed 12-month score, BL = Observed Baseline score, Δ = Delta or change score, RAVLT = Rey Auditory Verbal Learning Test, ADAS-Cog = Alzheimer’s Disease Assessment Scale – Cognition subscale, DS = Digit Span, TMT-A = Trail Making Test Part A, TMT-B = Trail Making Test Part B, BNT = Boston Naming Test, MMSE = Mini-Mental State Examination, MOCA = Montreal Cognitive Assessment. p value = significance of independent samples t tests examining the difference between the M12 – BL Δ performances between groups. Effect Size = Cohen’s d values for independent samples t tests.